Antioxidant status and miRNA

 ROS (Reactive Oxygen Species) are instable molecules synthesized either in physiological and pathological situation, we areexposed to then because of UV ray, pollution, combustions, stress, but they are naturally produced during cellular respiration too. Our body possess a machinery to inactivate it (vitamins and antioxidant enzymes). If there’s an imbalance between ROS production and inactivation by our body, they could modify organic molecules, particularly phospholipids (modifying structures and permeability of membranes), proteins (cutting down their biological function) and finally DNA (becoming a potential carcinogen) altering normal activity of cells. So it is mandatory, for a good health state, to manage this delicate equilibrium. We demonstrated how diet (in particular ketogenic diet) could positively regulate this mechanism and we assessed it via miRNA, small circulating RNA sequences, a novel way to have biological marker, we used too it to check diet progression and immunological status.