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The unmended DNA damage is essentially responsible for the destructive neurodevelopmental irregularities associated with Aicardi-Goutieres syndrome (AGS), an infrequent childhood disorder. The findings from Children's Research Hospital reverse the belief that inflammation of Neuro was to be guilt. The paper appeared today in Neuron. Working in a recently developed mouse model of human AGS, researchers showed that the enzyme loss RNASEH2 led to uncertainty of genome in highly dividing cells of the developing brain.
