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The study was conducted in sixteen goats of 6 months to 3 years of age suffering from enteritis, presented at teaching veterinary clinical complex, Rajuvas, Bikaner (Rajasthan). These goats were presented with the typical clinical signs and symptoms of diarrheic faeces, in appetence to anorexia, dull and depressed, and mild to moderate dehydration since the last 2-3 days. Blood and serum samples of all these enteritis affected goats were collected by standard procedures on the day first before initiation of the treatment. For therapeutic management, these goats were randomly divided in two groups (groups–I and II) containing 8 animals in each group. The animals of group–I were treated with ofloxacin at 5 mg/kg body weight by intramuscular rote daily and group-II were administered with a combination of sulphadiazine (400 mg/ml)+trimethoprim (80 mg/ml) at 1 ml/10 kg body weight intramuscularly daily for 3 days. In both groups supportive treatment in the form of NSAIDs (meloxicam), multivitamins (vitamin B1, B6 and B12) and fluid therapy (normal saline solution and Ringer’s lactate) was given in standard recommended doses for 3 days. After 3 days of regular treatment, it was found that the treatment regime provided to the goats of both group–I and group-II were recovered based on the remission of clinical signs and symptoms but group-I was considerably more effective.