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Introduction: The sexually transmitted infections-human immunodeficiency virus/acquired immunodeficiency syndrome constitute at this time, a serious health problem worldwide. Adolescence is considered a vulnerable risk group due to the typical risky sexual behaviour in this stage of life. Objective: Increase knowledge about sexually transmitted infectionshuman immunodeficiency virus/acquired immunodeficiency syndrome Method: Quasi-experimental study, in the teaching block: Luis Augusto Turcios Lima Polyclinic, San José de las Lajas during the period from January 2017 to December 2017. The methodology is established in the guidance manual on prevention of sexually transmitted infections-human immunodeficiency virus/acquired immunodeficiency syndrome of the National Institute of Hygiene, Epidemiology and Microbiology that consists of affective, participative, animation and reflection techniques. The universe was represented by 49 students belonging to the careers of nursing (12th grade) and fight and eradication anti-vectorial. Results: There is a significant increase in the levels of knowledge demonstrating the effectiveness of the intervention. Conclusions: The methodology used is useful to increase knowledge about sexual transmission infections
