Abstract

Materials and methods: In the Cell therapy department, Institute of Immunology and human genomics Academy of Science of Republic of Uzbekistan has developed an effective method of surgical treatment of DM by free implantation of islet cells of the pancreas cultures and introduced into clinical practice.

Results: The therapeutic effect of transplanted islet cells of pancreas in DM patients was assessed by the dynamics of the symptoms of diabetes. Disease of blood, serum, the need for exogenous insulin, the manifestation of macro- and microangiopathy. The dynamics of clinical manifestations of diabetes was studied separately in patients who received insulin before transplantation in a dose of less than or more than 40 units. As the examination of patients with implants of the islet cells of pancreas showed, within 9 months after the transplantation practically all disappeared clinical manifestations of the diabetes itself and its complications.

Conclusion: Thus, summing up the clinical results of islet cell transplantation along with the achievements, we noted that the problem bears in itself many more questions that await their resolution. There are also difficulties in isolating islet cells, insufficient number of cadaveric pancreas and good immunological protection.