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This experiment was conducted to assess the possibility of replacing fishmeal (FM) with Soybean Protein Concentrate (SPC) at different levels (Diet 1 (0%), Diet 2 (3.08%), Diet 3 (6.16%), Diet 4 (9.24%), Diet 5 (12.32%), Diet 6 (15.40%), Diet 7 (18.48%)), its effects on growth, serum biochemical indices and antioxidant activities, body composition, histology, intestinal flora and disease resistance in Litopaeneaus vannamei. There were three replicates in each group in the experiment (Initial mean weight = 0.23±0.00g) and were fed their respective diets for 8 weeks. Growth performance in Diet 6 compared to Diet 1, significantly increased (P < 0.05) and the survival rate ranged from 90% to 95%. No significant difference was observed among the groups in terms of crude protein, moisture, and ash content. There was an increase in serum acid phosphatase, alkaline phosphatase, High-Density Lipoprotein Cholesterol, Total Antioxidant capacity, Glutathione peroxidase. Significant decreases (P < 0.05) in Glucose and Total Cholesterol were observed in the shrimp.
