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Antimicrobial resistance (AMR) is one of the major leading problem and an issue for medical science in this era. The discovery of mcr-1 gene has led to medical science to hands off at present. This work aims to give a glance on plasmid-mediated mcr-1 gene mechanism of resistance to colistin in Escherichia coli and current status of mcr-1 in Faisalabad, Pakistan.