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The PESI score is an established prognostic score of the severity of the acute -pulmonary embolism (PE). A recent randomized trial established the identification of low-risk PE (PESI classes I and II), as possible criteria for outpatient treatment of acute PE. Simplified PESI (sPESI), that can be calculated using six equally weighted variabales (age, history of cancer, history of chronic lung disease - COPD or chronic heart failure - CHF, heart rate - HR, systolic blood pressure - BP, arterial oxyhaemoglobin saturation < 90%) can also provide reliable prognostic information. In the already published investigation, the simplified PESI was non-inferior for identification of low risk patients versus imaging and biomarker criteria proposed by the ESC. Patients with sPESI class 0 represented a low-risk PE. Unfortunately, sPESI based therapeutic regimen is still questionable.
