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Contrast medium injection is customarily thought to cause or exacerbate renal failure, although current research may temper this claim. Recent guidelines from the European society of urogenital radiology evaluated the safety measures before delivering contrast media. As long as the benefit risk ratio supports it, administering iodinated contrast medium is not contraindicated in the presence of kidney injury. The only proven method to avoid post iodine contrast nephropathy is intravenous hydration with sodium bicarbonate or 0.9% NaCl. When the glomerular filtration rate is less than 30 mL/min/1.73 m2, when the glomerular filtration rate is less than 45 mL/min/1.73 m2, or in patients with acute renal failure, it is necessary to do this when administering an iodinated contrast agent intravenously or intra arterially without first renal pass. The use of iodinated contrast medium should allow for the execution of pertinent investigations based on a benefit risk analysis and the use of preventative measures where appropriate.