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Drug addiction is a widespread issue across the world. It has an impact on the abuser's life as well as the public's health, which is a severe concern. Therefore, there is a significant need for the creation of new, potent treatments for drug addiction. There is a lot of interest in creating alternative tactics that broaden the use of small-molecule-based therapeutics given the limited success of small molecule medications. By changing the pharmacokinetics of the drug and lowering the concentrations of the drug in the central nervous system, the enzyme catalytic approach and the antibody-based trapping technique have been regarded as viable approaches to lessen the euphoria of drug users.