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INTRODUCTION: Fulminant hepatic failure (FHF), a term given to the acute liver injury causing sudden deterioration of hepatic function and encephalopathy within eight weeks of appearance of first symptom in a patient having no prior liver disease. It may be caused by toxins, drugs, viruses, or metabolic diseases, with viral hepatitis being the cause in 40-60% cases. In Pakistan, all types of hepatitis viruses are endemic, raising the prevalence up to 70-80%.
AIM: To evaluate etiology, clinical manifestations and outcome of FHF.
MATERIALS AND METHODOLOGY: This prospective observational study was conducted at the Department of Gastroenterology, Jinnah Postgraduate Medical Centre, Karachi, Pakistan from 2018 to 2019. All patients admitted with FHF were included in the study.
RESULTS: During the study period, 40 patients were enrolled, out of which 25 (62.5%) were males and 15 (37.5%) were females with a mean age of 26.03±9.95 years. Among the females, 12 were pregnant.
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