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Genetics can show the impact on heart. This disease can be transfer from the own families. These are caused by only one or a few changes of genetic that having a very force effect in causing disease. Known the condition called as a monogenic conditions, they involve uncommon disorders that affect mostly the heart's muscle (such as cardiomyopathy hypertrophic) or else electrical system (such as long QT syndrome). Another example is hypercholesterolemia which is familial, and also which causes very high in cholesterol levels and may lead to coronary artery premature.