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Skeletal variations among individuals play a critical role in understanding human health, evolution, and the development of skeletal disorders. This study explores the genomic underpinnings of skeletal variations, emphasizing how genetic factors influence bone structure and morphology. By employing advanced genomic techniques, including whole genome sequencing and genome-wide association studies (GWAS), we identify key genetic loci associated with variations in bone density, shape, and size. Our findings reveal that both common and rare genetic variants contribute significantly to skeletal diversity, highlighting the role of polygenic inheritance in bone morphology. Furthermore, we investigate the functional implications of these genetic variations, linking them to biological pathways involved in osteogenesis and bone remodeling. This research not only enhances our understanding of the genetic architecture of skeletal traits but also paves the way for future studies aimed at elucidating the relationship between genomic variations and skeletal diseases, offering potential avenues for therapeutic intervention and personalized medicine in bone health management.
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