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This study aimed to (1) explore the health issue experiences of postCOVID-19 and quality of life among people with Diabetes Mellitus (DM), (2) investigate the health issues and Quality of Life (QoL) postCOVID-19. A sequential exploratory mixed methods study was employed. A qualitative procedure was based on a grounded theory. Qualitative procedure: the 16 participants’ home in communities and primary hospital those were people with DM aged 18 years and above. A cross-sectional study was employed with totaled 200 participants. Descriptive statistic, Pearson correlation coefficient, and independent t-test were used. The five major themes emerged (1) moderate of QoL (2) mild and severe conditions, (3) fear of recurrence COVID-19 (4), split opinions: for and against COVID-19 vaccination, and (5) prevention of COVID-19. PCS were 66.5%, 62.0% fear of reinfection and fear of being unable to work and self-reliance, 47.5% fatigue/activity intolerance, 36.0% allergy, 28.0% cough, 24.5% loss of appetite, and 20.5% sleep disturbance, respectively. Most participants (89.5%) were unwillingness to COVID vaccination. Comparisons of QoL of men was more than women, age ranged <65 was more than aged ≥ 65 years, and nonhospitalization was more than hospitalization. Finally, the health issue was a negative relation of QoL (p < 0.01, r-.218). Conclusion: This study discovered that people with DM still have a lot of long COVID, not only physical but also psychological. Implication: Additionally, nurses can play a vital role in collaborating with the multidisciplinary team to create a health care services program tailored to people with DM’s needs.