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Tuberculosis disease has been recognized as one of the most dangerous diseases due to its high mortality level to the human population in the world. That problem becomes worse when the antitubercular drug resistance has been reported. Heterocyclic hydrazone derivatives, unique nitrogen-based organic compounds, have been reported for their pivotal role in the biological activity, especially on the antitubercular agent against Mycobacterium tuberculosis H37Rv. This review summarizes the up to date review of hydrazone derivatives application as the potential antitubercular agent. The effect of substituents and the presence of the heterocyclic moieties on the antitubercular activity were discussed.
