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DImmunity is the balanced state of the body to fight against diseases, unwanted invasion, tolerances and avoid allergic reactions. Tolerances is the failure to mount the immune system towards an antigen, that can be natural or self- tolerance. A failure to mount immune system is real important and a good thing, when it comes to the body’s own protein and other antigens. Autoimmune is the immune response against the body health cells and tissues. The healthy person needs to have good immune response to protect the one from diseases. Failure of the immune system to act against the diseases is called IMMUNODIFICIENCY. That may either due to primary causes such as genetic defects or secondary due to environment exposure, immunosuppression, cancer and aging. Lifestyle may lead to different exposure that can decrease the effectiveness of the immune response.The big point is on how our life style determines the health status by good protection against the infections. Basically, focusing on the social, mental and economic factors that may affect our health. Its wide cycle of which we do revolve in, as such when the person is affected economically, will be also affected socially and mentally, thus poor health status. For example, immune response is build up with good diet if then there is no diet, the result is no good health immunity. The social determinants are all conditions people are born, grow, live, work and age. Hence the probability of affecting the immune system of people born and live till aging in these social determinants is high. More efforts on the social determinants of health will decrease the risks of developing diseases and protecting the future generation.