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Extracellular Vesicles (EVs) are a broad class of membrane-bound nanoscale entities that are released into the extracellular environment by various cell types. By delivering their cargo, which includes proteins, RNA, DNA, lipids, metabolites, and tiny molecules to destination cells, they perform crucial roles in cell signalling. Recent research has indicated that EVs may control carcinogenesis by transporting cargo to recipient cells. Recent study has also shown that variations in plasma-derived EV levels and cargo in patients with metabolic illnesses have been noted by numerous researchers, indicating that EVs may be a promising source of disease biomarkers. Metabolites are one of the EV cargos that have recently garnered the most interest.