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This article has brought out and highlighted some Medicinal plants that have therapeutic potential due to the presence of natural antioxidants functioning as reducing agents, free radical scavengers and quenchers of singlet oxygen. Some of the plants selected for the present study, include: Withania somnifera (ASHWANGANDHA) Part Used Leaves, Aegle marmeleos (BEL) Part Used Leaves, Azadirachta indica (NEEM) Part Used Leaves, Ocimum sanctum (TULASI) Part Used Leaves, The goal of present research paper is to determine the use of certain kinds of Medicinal plants antimicrobial activity on Staphylococcus aureus, Bacillus coagulans and one Gram-negative—Escherichia coli, human pathogenic bacteria; and three fungal strains—Aspergillus niger, Tricoderma viride and Fusarium oxysporum. The antibacterial and antifungal activities of extracts (40, 60, 80,100 %) Zone of inhibition of the extracts were compared with that of standards- Streptomycin for antibacterial activity and Griseofulvin for antifungal activity. The results showed remarkable inhibition of the bacterial and fungal growth against the tested organisms.