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The vertebral column, or spine, is a complex structure that plays a crucial role in providing support, flexibility, and protection to the spinal cord. Individual differences in the vertebral column can arise from genetic, environmental, and developmental factors, leading to variations in anatomy, morphology, and function. This article reviews the individual differences found in the vertebral column, their embryological origins, and their clinical significance in diagnosing and managing spinal disorders. Understanding these variations is essential for healthcare professionals, particularly in orthopedics, neurology, and rehabilitation.