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The Aedes mosquito genus spreads the globally significant arboviral infection. More than 120 nations have endemic populations of this species, primarily in Southeast Asia, the Western Pacific, the Caribbean, Latin America, various US states, Africa, and the Middle East. Marked thrombocytopenia, severe hemorrhage, plasma leakage leading to shock or fluid accumulation with respiratory difficulty, and severe organ dysfunction are the hallmarks of severe dengue fever. Serology and viral antigen or nucleic acid detection are examples of confirmatory assays. Clinically difficult to differentiate from illnesses caused by the Zika and chikungunya viruses without diagnostic testing. The first vaccine to be licensed globally for the prevention of dengue is a tetravalent vaccination that has been approved in Mexico. Malaria is a major global source of mortality and morbidity that is brought on by protozoan parasites of the genus Plasmodium. These parasites have a convoluted life cycle in both their vertebrate hosts and mosquito vectors. The emergence of drug-resistant parasite strains, the expansion of insecticide-resistant mosquito strains, and the absence of licensed malaria vaccines with established efficacy are the main causes of malaria's return.
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