Abstract

Insulin resistance is considered as the major contributor for the development of NAFLD, but it is evident that genetic polymorphism also contribute for the development of necroinflammation and subsequent progression of disease. This study was aimed to compare the effect of insulin resistance and genetic polymorphism on the development of nonalcoholic fatty liver disease.

Materials and methods:

Forty-seven subjects with NAFLD and thirty four controls were selected for the study after ultrasonography of  eighty one consecutive apparently healthy subjects. Anthropometric profile [body mass index (BMI), waist circumference (WC) etc,], lipid profile, hepatic aminotransferases, fasting blood glucose (FBG), were recorded and value of homeostasis model assessment of insulin resistance (HOMA-IR) was analysed. PNPLA3 genotyping was also done. To see the association between insulin resistance, and genetic polymorphism with NAFLD was evaluated by multivariate logistic regression analysis after adjusting for potential confounding variables.