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Anatomical anomalies are variations from the typical structure or arrangement of organs, tissues, or body systems. These variations can occur across species and within individuals, presenting a complex landscape for researchers and medical practitioners. This review aims to provide a comprehensive overview of anatomical anomalies, exploring their classifications, causes, prevalence, clinical significance, and implications for medical practice and research. Through an examination of various examples and case studies, this article seeks to enhance understanding of anatomical anomalies and their importance in diverse fields such as anatomy, embryology, genetics, and clinical medicine.