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Introduction: Factors responsible for edema formation in a patient who had femoropopliteal bypass and its inhibitory effect on healing were examined in this study. Femoropopliteal bypass was performed with autogenous saphenous graft in a 50â€Âyearâ€Âold male diabetic patient with superficial femoral arterial occlusion of right leg. Antithrombin III defficiency was detected in the patient in whom wound healing was delayed and grade 2â€Â3 edema formation occurred in the operated leg. We think that detailed preoperative evaluation and meticulous surgical care could help in the prevention of this complication.