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Author(s): Josﾃδεﾂ津δづつｩ Maria Pereira de Godoy, Guilherme Beolchi, Maria de Fﾃδεﾂ津δづつ｡tima Guerreiro Godoy
Recently, the development of lymphedema has been reported in patients taking sirolimus after kidney
transplantation. The objective of the current study is to report on the association of sirolimus use with the
appearance of lymphedema and to suggest a palliative therapy.
The case of a 25ﾃδ｢ﾃやぎﾃつ笥earﾃδ｢ﾃやぎﾃつ塵ld simultaneous pancreas and kidney transplant patient, with complaints of edema of
the face and lower limbs after initiating treatment with sirolimus, is reported. Lymphoscintigraphy
demonstrated delay in the drainage of radiopharmaceuticals with lymph drainage improving the clinical
lymphedema but not the lymphoscintigraphic pattern. It was suggested that sirolimus therapy can trigger
functional lymphedema which is reversible with cessation of the drug and that lymph drainage produces
clinical improvement.
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