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Kibale National Park (KNP), Uganda also referred to as primate capital of the world is a home to several primate species including the endangered Eastern Chimpanzees (Pan troglodytes schweinfurthii). Road accidents have been reported globally to cause both direct and indirect negative impact on wildlife such as mortality from car accident collisions and alteration of natural landscape which may have an impact on behavioural patterns of wildlife respectively. This case reports presents post-mortem findings in an oestrous subadult chimpanzee involved in a speeding car accident along Fort Portal-Kampala Road through KNP and was reported dead on spot. Physical examination of the cadaver indicated good overall body condition; at 30 kg, the deceased female was on oestrous one with mild swelling The left and right mammary gland was of normal size with no signs of any lactation recent lactation. The individual was on estrous one by the time of death There was marked cardiac laceration around the right ventricle. The recoil of the skull led to the damage of the brain and hemorrhages. From the above findings, the probable cause of death is attributed to effects from blunt trauma force and collision from the car followed by a cascade of hypovolemic shock from internal hemorrhage (and brain damage) secondary to contralateral brain hemorrhage.