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Wide distribution of antibiotic resistant infections is a global challenge to public health. Pre-treatment of drug resistant bacteria with newly developed iodine-containing complex FS-1 makes them sensitive to regular antibiotics. This phenomenon was demonstrated in vitro and in clinical trials on multidrug resistant Mycobacterium tuberculosis, Staphylococcus aureus, Escherichia coli and Acinetobacter baumannii. Possible mechanisms of drug resistance reversion were studied experimentally and by deep DNA and RNA sequencing using PacBio and Ion- Torrent technologies on two reference strains – MRSA S. aureus ATCC BAA-39TM and ESBL E. coli ATCC BAA- 196TM. In both cases, a stable reversion to antibiotic sensitive phenotype was achieved associated with alterations in gene expression patterns reflecting a general oxidative stress and deregulation of drug resistance mechanisms.
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