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Spermidine and spermine are unique polyamines found in living things. Putrescine and S-adenosylmethionine are created in the body through an enzyme-catalyzed process. Multiple amino groups are present in spermidine and spermine, which are also tightly linked to cell development, division, and survival. In plants, microorganisms, and marine species, spermidine and spermine alkaloids are extensively dispersed and can be categorized as macrocyclic and open chain compounds based on their skeletons. The pharmacological effects of spermidine and spermine alkaloids included anti-inflammatory, antibacterial, anti-tumor, anti- Alzheimer's, and anti-viral properties. However, there haven't been many comprehensive reviews of spermidine and spermine alkaloids up to this point. We have outlined the distributions and pharmacological effects of spermidine and spermine alkaloids in this review based on the number of atoms in the ring.
