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Since 2000, the risk of chronic renal disease with no recognised cause has increased significantly throughout the Mesoamerican region. Various theories have attempted to explain the aetiology of the novel disease known as Meroamerican Nephropathy (MEN), including de-hydration, heat stress, environmental or chemical exposure, or even infections. Young men and agricultural labourers who operate in hot environments are affected by MEN. MEN courses have a wide range of symptoms, including as lowgrade fever, dysuria, and progressive kidney disease with disturbedhydroelectrolyte balance. A kidney bi-opsy must be performed to confirm the diagnosis of tubule interstitial nephritis (usually at chronic stage). Even though MEN diseases have a high morbidity rate in en-demic areas, there is no specific treatment for them, and only prophylactic measures have shown any effect on prognosis (avoid heat stress, constant hy-dration).
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