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Nanotechnologists began studying nanomaterials for medical uses more than a decade ago. This study uncovered a wide range of obstacles as well as numerous opportunities. Some of these concerns are closely related to informatics issues, such as managing and integrating heterogeneous data, developing nomenclatures, taxonomies, and classifi- -cations for diverse types nanomaterials, and research on novel nanoparticle modeling and simulation tools. To solve these difficulties, nano-informatics has recently evolved in the United States and Europe. We describe the roots of nano-informatics, the problems it solves, areas of interest, and examples of contemporary research activities and informatics resources in this study.