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Chronic hepatic children are especial category with difficult cannulation causing distress to children from repeated trials for preparation before follow up procedures as they have fragile veins or vein fibrosis in addition the bad clinical condition for day case procedures and the psychic trauma they had. Aim In this study we aim to assess the effect of nebulized Dexmedetomidine on sedation, face mask acceptance, emotional separation scores before upper endoscopy.