Novel approaches for transdermal drug delivery of curcumin

Author(s): Krishna Sailaja

Aim:-Transdermal drug delivery system has become a proven technology that offer significant clinical benefit over the dosage forms. Drugs with very short half-life, narrow therapeutic window, and poor bioavailability-transdermal drug system are convenient. Skin serves as site of drug application for local as well as systemic effects. This works provides the valuable information regarding the transdermal drug delivery system and highlights the detailed role of physical penetration and recent advance techniques such as iontophoresis, sonophoresis, microneedles, electroporation, ethosomes and transferosomes. Formulation of curcumin loaded ethosomal formulation by hot method was discussed in detail. Materials and Methodology: For the preparation of curcumin, loaded ethosomes hot method was adopted. Nine different formulations were prepared by varying the drug to lipid ratio (E1, E2, E3, E4, E5, E6), ethanol concentration (E7, E8, E9). DMSO was used as solubilising agent and soya lecithin as lipid, ethanol, as solvent, propylene glycol as permeation enhancer.The prepared formulations are evaluated for their particle size, entrapment efficiency, drug content, product yield, zeta potential drug release studies,permeability studies, SEM and mean vesicle size.
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