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Background: Age-related loss of volume and imperfections in the face or neck can lead to psychological discomfort due to the stigmatization of these physical changes, potentially catalyzing uncomfortable interpersonal relationships. The aim of this retrospective study was to evaluate the patients’ perceived improvement and safety regarding a new 2.5% (mg/ml) hyaluronic acid–based filler developed with a conservative cross-linking technology and purified by a dialysis procedure through water for injection (BDDE<0.1 ppm).
Methods: Patient’s perceived improvement and treatment safety recorded from the first treatment to the last follow-up were retrospectively analyzed.
Results: Four hundred and seven patients (mean age: 51.4 ± 11.2) were included, totaling 1,070 treatments (2.63 ± 2.25 vials per subject). More than 98% of patients expressed high perceived improvement level. Mild and transient side effects (mainly hematoma and pain) occurred in 55% of patients; in many cases, these side effects disappeared without pharmacological treatment.
Conclusion: This new hyaluronic acid filler has proven capable of achieving aesthetic natural-looking results, maintaining high effectiveness in the long-term, and demonstrating an excellent safety and tolerability profile, even when repeated treatments are required.
