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Stem cells are a population of undifferentiated cells which have the ability to proliferate usually to develop from a single cell clone and can be divided into different types of cells and tissues. There are several sources of stem cells with different potencies. Pluripotent cells are embryonic stem cells and from the internal cell mass of the embryo and induced pluripotent cells, resulting from the somatic cell reprogramming. Pluripotent cells can differentiate into tissues from 3 germ layers. Regenerative medicine is a new development in the medical science that deals with the functional restoration of tissues or organs from a patient who is suffering from severe injuries or chronic diseases. An impressive progress in the research of stem cells provides a basis for cell therapy for diseases that are not cured with conventional medicine. Undefined, self-repair, and the ability to differentiate into other cell types are stem cells, and the limits of regenerative medicine. The Trans differentiating potential of stem cells varies depending on the source, and regenerative medicine applications to change as well.