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E.coli is one of the main cause of nosocomial infection in humans. E.coli being one of the common organism causing hospital acquired infections exhibits ESBL production Causing resistant to Beta lactam group of drugs resulting in limited treatment options. Hence, this study was done to know the resistance pattern in E.coli and their virulence factors. Materials and Methods: Samples (urine, pus, sputum) were collected & processed as per standard protocols E.coli were isolated. Antibiogram done as per CLSI guidelines. ESBL & MBL screening done, Biofilm formation of E.coli was studied in correlation to antibiotic resistance. Result: 235 E.coli were isolated from various clinical samples. Out of 235, 148 (62.97%) showed resistance to ceftazidime & cefatoxime, 53 (22.55%) were ESBL producers, 19 (8.8%) showed resistance to imipenem, 32 (1.27%) were MBL producer. E.coli were resistant to nalidixic acid, 119 (50.6%) followed by Cotrimoxazole 98(41.7%), Ciprofloxacin resistance was 135 (57.6%) and MIC ranged from 8- 64 ?g/ml. Among 235 E.coli isolates 169 (46.38%) were MDR of which 29 (12.34%) were strong biofilm producers. Conclusion: This study highlights that all isolated ESBL producers were resistant to 3rd Gen. cephalosporins.
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