Abstract

Background: Inflammation has been reported as a facilitator in cervical oncogenesis, but the correlation between inflammation and cytology abnormality

including cervical intraepithelial neoplasia (CIN) remains uncertain. The aim of this study was to investigate the correlation between them with ThinPrep

cytological test (TCT) as a screening tool for cervical cancer and CIN, which can identify abnormal morphology of cervical mucosa epithelium and inflammation

degrees in TCT reports. However, doctors often focus on the cytology abnormality in TCT reports while ignore the inflammation degree functions.

Methods: In this study, we collected clinical data from 48101 women undergoing TCT in the affiliated hospitals of Sun Yat-Sen University

(1). We suggested that TCT was an effective screening tool of CIN, and HISL has a close relationship with CIN3

(2). We pointed out the high risk of HISL by inflammation degrees

(3). We examined the inflammation degrees in the cytological abnormality slides and revealed the positive correlation between inflammation and different

stages of cytological abnormality

(4). In addition, we investigated the risk prediction value of inflammation degrees for HISL by logistic analysis.