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Peripheral ossifying fibroma (POF) is an infrequently occurring, slowly progressing, innocuous, nodular overgrowth of the gingiva, which belongs to the category of the “reactive lesions of the gingiva.” There are several such overgrowths with similar clinical manifestations, but diverse etiology and histopathological features, thus presenting a challenge for the clinician. Through anamnesis, clinical, radiographic and histopathological analysis helps to establish the diagnosis which is key to the successful management of such lesions. This article describes a case of POF in a 43-year-old male patient. The scientific data pertaining to the clinical, radiographic, histologic features, aggressive treatment strategies, relapse and close follow-up of POF are discussed in detail. The article also stresses on the importance of differential diagnosis.
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