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Major immune system regulators and effectors are neutrophils. They are crucial in the development and spread of cancer as well as the eradication of infections. On the other hand, neutrophil activity, development, and lifespan are impacted by the presence of cancer. Cancer cells take advantage of neutrophil biology by enhancing or suppressing vital neutrophil functions. One notable neutrophil pathogen defense mechanism that has been co-opted in this process is the creation of Neutrophil Extracellular Traps (NETs). NETs are filamentous extracellular web-like structures made of DNA, histones, and proteins produced from cytotoxic granules. Here, we talk about the reciprocal interactions between cancer and NETs, which promote the development of the disease. We examine how an increased risk of cardiovascular death is induced by vascular dysfunction and thrombosis brought on by neutrophils and NETs. Heart problems in cancer patients. Finally, we suggest potential therapeutic approaches for fighting NETs in a clinical environment.
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