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The temporal bone, a complex structure housing vital components of the auditory, vestibular, and neurovascular systems, plays a crucial role in otologic and neurosurgical procedures. Anatomical variations within the temporal bone, though often subtle, can significantly influence surgical outcomes, complicating procedures such as cochlear implantation, mastoidectomy, and skull base surgery. This review explores common and uncommon anatomical variations of the temporal bone, including facial nerve anomalies, variations in the mastoid air cell system, internal auditory canal abnormalities, and temporal bone fractures. These variations can increase the risk of surgical complications, including nerve damage, hearing loss, and poor postoperative recovery. The identification of these variations through advanced preoperative imaging techniques such as CT and MRI is essential for optimizing surgical planning, reducing risks, and improving outcomes in otologic and neurosurgical interventions. Understanding these anatomical differences enables surgeons to adapt their techniques, ensuring safer and more effective procedures.