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The human body is a marvel of complexity, composed of various organ systems working harmoniously to maintain homeostasis and support life. This article provides a comprehensive review of the organ systems, outlining their structures, functions, and interactions. Beginning with an overview of the organization of the human body, the article explores each major organ system in detail, including the integumentary, skeletal, muscular, cardiovascular, respiratory, digestive, nervous, endocrine, urinary, and reproductive systems. Emphasis is placed on the interdependence and coordination between these systems, highlighting their collective role in sustaining health and vitality. Furthermore, clinical correlations are discussed to illustrate the relevance of organ system dysfunction to medical practice and healthcare. Overall, this article serves as a valuable resource for students, educators, and healthcare professionals seeking a deeper understanding of the intricacies of the human body.