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Neuroanatomy plays a crucial role in clinical practice, aiding healthcare professionals in diagnosing and managing neurological disorders. This case report highlights the significance of neuroanatomical knowledge in diagnosing a patient with a rare neurological condition. The case involves a 45-year-old male presenting with progressive gait disturbance and muscle weakness. A comprehensive neurological examination and diagnostic workup revealed a lesion in the corticospinal tract, emphasizing the importance of neuroanatomy in clinical decision-making and patient care.