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The obturator artery and inferior vesical artery originate from the internal iliac artery. Variation in their origin may be asymptomatic in individuals and occasionally be detected during routine cadaveric dissections or autopsies. This case reports a variation in the origin of the obturator artery and inferior vesical artery. Here, not only did the obturator artery originate from the external iliac artery, but also gave rise to the inferior vesical branch. Prior knowledge of the anatomical variations may be beneficial to the vascular surgeons ligating the internal iliac artery or its branches and the radiologists interpreting angiograms of the pelvic region.