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The digestive tract is a complex system responsible for the breakdown and absorption of nutrients. Variations in its anatomy can arise due to genetic, environmental, and developmental factors, affecting both physiological function and clinical outcomes. This article reviews the anatomical variations found in different segments of the digestive tract, their embryological origins, and the clinical significance of these variations in diagnostics and surgical practices. A thorough understanding of these variations is essential for healthcare professionals, particularly those involved in gastroenterology and surgery.