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Since the Transfusion Requirements in Critical Care (TRICC) trial's findings, which supported the limitation of Red Blood Cell (RBC) transfusions in the sickest patients, were published, more than ten years have passed. Several accounts show that transfusion procedures have changed since then. Allogeneic blood transfusions have a long history of being associated with a variety of dangers and issues. While some dangers have been greatly reduced thanks to developments in blood banking, they are unlikely to ever be completely removed. Other dangers and issues are more challenging to handle since their causes seem to be more elusive and subtle. Leukocytes, leftover plasma, and blood storage issues have all been looked into as potential sources of negative effects from banked allogeneic blood. Notably, numerous clinical research investigating the effects of blood storage age on patient outcomes are now being conducted. If the results of these experiments show that the currently approved shelflife of banked blood is too lengthy and should be reduced, it might significantly alter the transfusion practice landscape.
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