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Serious Intense Respiratory condition Covid 2 (SARS-CoV-2) has made a pandemic all through the world, most eminently causing passing attributable to pneumonia and cytokine storm disorder. The treatment is exceptionally strong with no complete antiviral treatment and intends to reduce hypercytokinemia notwithstanding forestall further difficulties during viral freedom. Helpful plasma trade is the partition of plasma from other blood segments and can possibly clear cytokines which causes the “storm”. Two fold Filtration Plasmapheresis is powerful of evacuation of particles huger than 55 nm-60 nm and the strategy stands the reasoning of potentially clearing SARS-CoV-2 (60-140 nm) from blood. In this article we might want to feature the useful capability of plasmapheresis in spite of the fact that it’s anything but’ a doubtful methodology.