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We present three cases of patients with icteric syndrome and various symptoms, misdiagnosed for acute viral hepatitis and targeting an infectious clinic. In all three cases, important differential diagnosis laboratory and instrumental examinations have been disregarded and the patients are diagnosed only on the basis of questioning and physical examination. We encourage the use of laboratory tests and accessible and non-invasive imaging methods such as abdominal ultrasound, in outpatient settings, before making a definitive diagnosis.