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Journal of Neurology and Clinical Neuroscience | Volume: 03
8
th
International Conference on
NEUROLOGICAL DISORDERS,
CENTRAL NERVOUS SYSTEM AND STROKE
&
International Conference on
NEUROLOGY AND NEUROSURGERY
December 04-05, Dubai, UAE
Joint event on
J Neurol Clin Neurosci, Volume: 03
M
archiafava-Bignami Disease (MBD) is a neurological
disorder that has been found to be associated with
chronic alcoholism and malnutrition. We report a 45 year
old man, chronic alcoholic that developed discouragement
for activities involving daily living, changes in retrograde
memory in addition to mutism and gait instability. Brain
MRI showed central atrophy of the corpus callosum,
hypointensity (necrosis) and ventricular dilation(white
matter and subcortical region involvement). Pathological
characteristics include isolated demyelination and axonal
loss in the central layer of the CC sparing the dorsal and
ventral layer. This pattern of necrosis of the middle layer
of the CC is a typical finding in the disease. The clinical
diagnosis has considerably changed during recent decades
after brain MRI provided the opportunity of a reliable in-
vivo diagnosis. With early detection and treatment, the
prognosis of MBD may be good.
Biography
Caio Pontes has special interest in neurological complications of alcohol
abuse, demyelinating disease and advances in diagnostic tools. He worked
as neurological member of the Federal institution (Hospital Federal dos
Servidores do Estado – RJ) which is reference in neurological diseases.
e:
caio.m88@gmail.comCaio Pontes
Hospital Federal dos Servidores do Estado, Brazil
The Importance of Brain MRI in the diagnosis of Marchiafava-
Bignami Disease