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Volume 3 Dentistry Case Report Euro Dentistry 2019 & Dental Science 2019
July 15-16, 2019
July 15-16, 2019 | London, UK
27th Global Summit Expo on
&
27th EURO DENTISTRY CONGRESS
DENTAL SCIENCE AND DENTAL PRACTICE
Dentistry Case Report, Volume 3
Simvastatin chitosan gel: A new approach for extraction socket healing and alveolar
bone preservation
Youmna M Sherif
Alexandria University, Egypt
Healing of the extraction socket has been the area of concern of many studies over the past years, due to the occurrence
of post-extraction bone resorption and therefore, in many cases, the failure of implant placement, fixed or removable
prosthesis. There have been many studies demonstrating the bone-promoting effect of simvastatin local application in animal
models. Simvastatin in combination with chitosan is shown to increase bone volume, bone formation rate, and bone compressive
strength along with inhibiting the osteoclastic activity, thus inhibiting alveolar bone resorption. The first experimental evidence
in an animal model of the osteo-modulador effect of statins was reported by Mundy et al who demonstrated that treatment
with simvastatin resulted in a significant increase in the rates and bone formation markers, and that the effect of statins were
comparable to that induced by treatment with bone morphogenetic protein-2 (BMP-2) and fibroblast growth factor, which are
known stimulants of bone metabolism. Thus, this study aims at examining the influence of simvastatin chitosan gel on bone
healing in extraction socket of first molar in rat mandibles and developing an injectable affordable material that preserves the
alveolar bone architecture by enhancing bone regeneration and preventing bone resorption, where the specimens were processed
for scanning electron microscopy and detection of Vascular Endothelial Growth Factor and Fibronectin immunohistochemically.
Biography
Youmna M Sherif has her expertise in oral biology specifically bone biology and regeneration. Her experimental model for a proposed
bone healing enhancement material creates new pathways for improving post-dental extraction recovery. She has built this model
after years of experiments and research, along with teaching the basics of oral biology and dental morphology to freshmen students.
The foundation of this research is based on the fact that statins show an impressive range of effects in the human body and can be
leveraged for a wide variety of potential applications.
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