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Page 33

Food Science 2019

November 11-12, 2019

Food Science and Technology

November 11-12, 2019 | London, UK

3

rd

International Conference on

Volume 3

Applied Food Science Journal

Appl Food Sci J. | Volume 3

Linking diet, Gut immunity and Microbiota in the pathogenesis of Type 1 diabetes

Ilaria Cosorich

University Vita-Salute San Raffaele, Italy

R

ecent data indicate that gut immunity and the mechanisms that regulate effector and regulatory T cell

differentiation in the intestine are instrumental to maintain immune tolerance towards self-tissues and to

prevent extra-intestinal autoimmune diseases. This observation led to the hypothesis that environmental factors

as diet and microbiota modifications, affect the pathogenesis of autoimmune Type 1 Diabetes (T1D). To this aim,

we analyzed gut mucosal immunity in tissue samples isolated from the small intestine of T1D patients and healthy

controls (HC). A phenotypical analysis of gut mucosal immune cell subsets has been performed. We observed a

statistically significant increase of Th22cells and CD1c+CX3CR1+ dendritic cells (DCs) in the gut of T1D patients

compared to HC. In order to find if there is a correlative link between diet component and immune cells subsets,

we are collecting a 3-days-food record questionnaire from T1D patients. At this stage we still have not found

correlations between the percentage of different Th subsets and content of fiber and polyunsaturated/saturated fat

from the diet. Gut microbiota of brushing material from duodenum was analyzed by 16S rRNA sequencing. We also

investigated if different type of diet can influence autoimmunity in preclinical models of T1D. In particular if a high

fat diet can activate the diabetogenic T cells in BDC2.5 mice, and whether if an anti-inflammatory diet enriched in

fiber and omega3 can reduce gut inflammation and protect NOD mice from T1D. We further aim at elucidating the

link of gut immunity alterations and environmental factors that might have a strong impact on T1D.

Biography

Ilaria Cosorich has completed master’s degree in Garvan institute of Medical Research and from then she started working as a

Research assistant at Diabetes Research Institute and further she graduated her doctorate from University Vita-Salute San Raffaele

University. Her project is focused on intestinal immunology and nutrition in type 1 diabetes and multiple sclerosis. Currently she is

pursuing Post-doctorate at San Raffaele Hospital.

cosorich.ilaria@hsr.it