microbiology-reproductive-health-2017-keynote

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Journal of sexual and Reproductive medicine | Volume.1, Issue.2
Page 10
Notes:
3rd International Congress on
Annual Summit on
October 02-03, 2017 Atlanta,USA
&
Microbiology and Pharmaceutical Microbiology
Sexual & Reproductive Health
Ian James Martins
Edith Cowan University, Australia
Bacterial lipopolysaccharides (LPS) accelerates diabetes: Acute epilepsy and
neurodegenerative disease
Diabetes in the world has reached epidemic proportions with mitochondrial disease related to programmed
cell death in various cells. The nuclear-mitochondrial interaction in diabetes is defective with concerns
that increased plasma levels of bacterial lipopolysaccharides (LPS) are involved in mitochondrial disease and
programmed cell death. Western diets with overnutrition promote LPS absorption with increased plasma LPS
levels. Drug therapy in diabetes has become essential to prevent mitochondrial disease but LPS effects override the
drug therapeutic effects withmitochondrial apoptosis. LPS inserts itself into cell membranes and is now considered
a major repressor of the anti-aging gene Sirtuin 1 (Sirt 1) and is a competitive inhibitor of Sirt 1 actions involved
in the regulation of cholesterol and glucose homeostasis. LPS neutralizes apolipoprotein E relevant to membrane
amyloid beta aggregation in diabetes and neurodegenerative diseases. Diagnosis of diabetes, dyslipidemia and
nonalcoholic fatty liver disease may now involve plasma LPS levels in global communities to avoid inadvertent
errors by other clinical tests. Healthy diets that activate Sirt 1 actions are essential reverse chronic diseases in
diabetes with low calorie diets essential to reduce LPS effects. Poor hygiene, skin lesions, microbiological food
contamination and elevated intestinal LPS transport induce LPS mediated mitochondrial apoptosis that supersede
adenosine treatment relevant to recurrent epilepsy and seizures in diabetes and neurodegenerative diseases.
Biography
Ian James Martins has been invited to join the editors of various international journals and has been a reviewer for various journals (approx. 40). He was appointed
as the Chief Editor for International Journal of Diabetes Research (2014-2017). He is a BIT Member (BIT Congress. Inc) with an H-index of 42, (ResearchGate
STATs (22), Mendeley STATS (20). The total citations over the past 27 years has accumulated to 2830. ResearchGate’s analysis available on google, Tweet,
Facebook, LinkedIn. He has received certificates of recognition at various conferences/congresses in relation to anti-aging medicine. Prevention of over eating by
food restriction improves the peripheral sink hepatic a beta clearance relevant to liver lipid metabolism important to improving health and global chronic diseases.