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Volume 3
Journal of Pharmacology and Medicinal Chemistry
Nanomedicine 2019
Biotechnology 2019
May 20-21, 2019
May 20-21, 2019 London, UK
4
th
World Biotechnology CONGRESS
Nanomedicine and Nanotechnology
4
th
International Conference on
&
Delivery method of the silencers RNA by PBCA nanoparticles for the treatment of
multiform glioblastoma
Cyro von Zuben V Negrão
University of Campinas, Brazil
G
lioblastoma multiform (GBM) has been reported as the most severe and the deadliest brain cancer, with a prognosis of
only 14 months. Treatment is executed by the extraction of the tumor, followed by a radiation therapy and chemotherapy.
Nowadays, brain therapy has found great obstacles to become effective due to factors such as the drug resistance and the
difficulty to cross the blood-brain barrier. One of the great promises for the diagnosis, treatment and precaution of several
diseases has been the use of nanoparticles (NPs). Among the different types of NPs, the PBCA nanoparticles have been
gaining space in medicine because of its unique properties and its multiples employability. PBCA nanoparticles also have
the ability to cross the blood-brain barrier (BBB). Another great promise in the treatment of diseases is the use of interfering
RNA technique by presenting a specific and unique gene silencing capacity through molecules denominated in this project a
silencers RNA. Several researches have been conducted focusing on several categories of cancers, which have been employed
different NPs, as well as the use of diverse silencers RNA. The aim of this project is to create a delivery method of RNA
silencers by nanoparticles for the treatment of GBM. So, to achieve it, different mechanisms will be used in the topography
of PBCA-NPs to make them specific tumor tissue, besides using the silencers RNA focused on genes that brings resistance to
most important drug and also genes responsible for the maintaining of tumor cells in different lines cell: U87/U118-GM and
patients cells. Therefore, the main purpose of this project is to create an alternative method of treating one of the deadliest
cancers from two scientific pillars of major biotechnological fields of modern medicine: nanoparticles and interfering RNA.
Biography
Cyro von Zuben, PhD student has his expertise in interfering RNAs (RNAi). He worked with the use of RNAi tool for the control of pests
in the agriculture, by which he awarded as the first place in Congress Open for Biology Students (2013) and he was selected for the
oral presentation in 10th Latin Congress of Entomology (2018th). Actually, he has a team in the best University of Latin America with the
professor Henrique Marques-Souza to found news genetics molecules for the most important Brazilian pests. This technology was also
awarded as the best technology by the companies that were present in Open Innovation Week (2018). Last year, Cyro was approved
on the program “New Talents” of one of the most prestigious and famous Institute of Brazil: Institute for Technological Research. By
now, he is developing the nanoparticles with the RNAi technology for the treatment of diseases as cancer.
cyrozvn@ipt.comJ Pharmacol Med Cheml, Volume 3